I wanted to write this up in case some one else runs into a similar issue.
The problem experienced was that all the ROMs I played were running incredibly slow. The video and audio playback of them was slow and choppy.
THIS IS NOT A POLYCADE ISSUE
And it isn't really a RetroArch issue either.
The root of my issue turned out to be that I am using a 4K monitor and an Nvidia graphics card. My Nvidia video settings were set to 4K but only 30hz. I needed to update the video settings to 60hz and that fully resolved my issue.
I should have known as I've encountered similar issues after moving my setup to 4K.
Hope this helps someone in the future.